Article
PEAR1 is not a human hypertension-susceptibility gene.
Blood pressure - 1 Feb 2015
Olivi Laura, Vandenbriele Christophe, Gu Yu-Mei, Salvi Erika, Carpini Simona Delli, Liu Yan-Ping, Jacobs Lotte, Jin Yu, Thijs Lutgarde, Citterio Lorena, Cusi Daniele, Verhamme Peter, Staessen Jan A
Abstract excerpt
OBJECTIVE: Platelet endothelial aggregation receptor 1 (PEAR1) is a membrane protein involved in platelet contact-induced activation and sustained platelet aggregation. Experimental studies identified PEAR1, as a candidate gene that may be linked to the blood-pressure driven kidney injury in salt-sensitive Dahl rats. AIM: In a family-based European population study (mean age 39.7 years; 52.2% women), we searched...
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