Article
The effects of immune protein CD3ζ development and degeneration of retinal neurons after optic nerve injury.
PloS one - 1 Jan 2017
He Tao, Mortensen Xavier, Wang Ping, Tian Ning
Abstract excerpt
Major histocompatibility complex (MHC) class I molecules and their receptors play fundamental roles in neuronal death during diseases. T-cell receptors (TCR) function as MHCI receptor on T-cells and both MHCI and a key component of TCR, CD3ζ, are expressed by mouse retinal ganglion cells (RGCs) and displaced amacrine cells. Mutation of these molecules compromises the development of RGCs. We investigated whether...
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