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Article

Retinal ganglion cell loss after the period of naturally occurring cell death in bcl-2-/- mice.

Neuroreport - 6 Apr 1999

Cellerino A, Michaelidis T, Barski J J, Bähr M, Thoenen H, Meyer M

Abstract excerpt

Over-expression of Bcl-2 is known to reduce the extent of retinal ganglion cell death during development as well as after axotomy. Here we investigated whether retinal ganglion cell (RGC) numbers are reduced in mice with a targeted inactivation of the bcl-2 gene. Compared with wild-type mice, adult bcl-2 null mutants have lost 29% of the retinal ganglion cell axons in the optic nerve. This reduction was almost...

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Identifiers

PMID: 10321489
DOI: 10.1097/00001756-199904060-00034

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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