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Article

Structural correlation between the nerve fiber layer and retinal ganglion cell loss in mice with targeted disruption of the Brn3b gene.

Investigative ophthalmology & visual science - 13 Jul 2011

Camp Andrew S, Ruggeri Marco, Munguba Gustavo C, Tapia Mary L, John Simon W M, Bhattacharya Sanjoy K, Lee Richard K

Abstract excerpt

PURPOSE: Mice with a targeted disruption of Brn3b (knockout Brn3b(-/-)) undergo the loss of a majority of retinal ganglion cells (RGCs) before birth. Spectral domain optical coherence tomography (SD-OCT) allows for the noninvasive examination of Brn3b(-/-) cellular loss in vivo. METHODS: The central retinas of Brn3b(-/-) and phenotypically wild-type (Brn3b(+/+) and Brn3b(±)) mice were imaged by SD-OCT. The...

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Identifiers

PMID: 21622702
DOI: 10.1167/iovs.10-6307
PMCID: PMC3176044

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