Article
POU domain factor Brn-3b is essential for retinal ganglion cell differentiation and survival but not for initial cell fate specification.
Developmental biology - 15 Jun 1999
Gan L, Wang S W, Huang Z, Klein W H
Abstract excerpt
While the mammalian retina is well understood at the anatomical and physiological levels, little is known about the mechanisms that give rise to the retina's highly ordered pattern or its diverse neuronal cell types. Previous investigations have shown that gene disruption of the POU-IV class transcription factor Brn-3b (Brn-3.2) resulted in the loss of most retinal ganglion cells in retinas of postnatal mice....
Topics
- Alkaline Phosphatase
- Alleles
- Animals
- Apoptosis
- Cell Differentiation
- Cell Movement
- Cell Survival
- DNA-Binding Proteins
- Embryonic and Fetal Development
- Gene Expression Regulation, Developmental
- Heterozygote