Article
The signaling adaptor protein CD3zeta is a negative regulator of dendrite development in young neurons.
Molecular biology of the cell - 1 Jun 2008
Baudouin Stéphane J, Angibaud Julie, Loussouarn Gildas, Bonnamain Virginie, Matsuura Akihiro, Kinebuchi Miyuki, Naveilhan Philippe, Boudin Hélène
Abstract excerpt
A novel idea is emergxsing that a large molecular repertoire is common to the nervous and immune systems, which might reflect the existence of novel neuronal functions for immune molecules in the brain. Here, we show that the transmembrane adaptor signaling protein CD3zeta, first described in the immune system, has a previously uncharacterized role in regulating neuronal development. Biochemical and...
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