Article
MEF2 transcription factors differentially contribute to retinal ganglion cell loss after optic nerve injury.
PloS one - 1 Jan 2020
Xia Xin, Yu Caroline Y, Bian Minjuan, Sun Catalina B, Tanasa Bogdan, Chang Kun-Che, Bruffett Dawn M, Thakur Hrishikesh, Shah Sahil H, Knasel Cara, Cameron Evan G, Kapiloff Michael S, Goldberg Jeffrey L
Abstract excerpt
Loss of retinal ganglion cells (RGCs) in optic neuropathies results in permanent partial or complete blindness. Myocyte enhancer factor 2 (MEF2) transcription factors have been shown to play a pivotal role in neuronal systems, and in particular MEF2A knockout was shown to enhance RGC survival after optic nerve crush injury. Here we expanded these prior data to study bi-allelic, tri-allelic and heterozygous allele...
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