Genomic consequences of aberrant DNA repair mechanisms stratify ovarian cancer histotypes.

doi:10.1038/ng.3849

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Article

Genomic consequences of aberrant DNA repair mechanisms stratify ovarian cancer histotypes.

Nature genetics - 1 Jun 2017

Wang Yi Kan, Bashashati Ali, Anglesio Michael S, Cochrane Dawn R, Grewal Diljot S, Ha Gavin, McPherson Andrew, Horlings Hugo M, Senz Janine, Prentice Leah M, Karnezis Anthony N, Lai Daniel, Aniba Mohamed R, Zhang Allen W, Shumansky Karey, Siu Celia, Wan Adrian, McConechy Melissa K, Li-Chang Hector, Tone Alicia, Provencher Diane, de Ladurantaye Manon, Fleury Hubert, Okamoto Aikou, Yanagida Satoshi, Yanaihara Nozomu, Saito Misato, Mungall Andrew J, Moore Richard, Marra Marco A, Gilks C Blake, Mes-Masson Anne-Marie, McAlpine Jessica N, Aparicio Samuel, Huntsman David G, Shah Sohrab P

Abstract excerpt

We studied the whole-genome point mutation and structural variation patterns of 133 tumors (59 high-grade serous (HGSC), 35 clear cell (CCOC), 29 endometrioid (ENOC), and 10 adult granulosa cell (GCT)) as a substrate for class discovery in ovarian cancer. Ab initio clustering of integrated point...

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PMID: 28436987
DOI: 10.1038/ng.3849

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BRCA1
BRCA2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-28436987-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

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