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Exploring the somatic mutational landscape of ovarian cancer in Estonia.

Acta oncologica (Stockholm, Sweden) - 18 May 2026

Tooming Mikk, Rekker Kadri, Toome Kadri, Roht Laura, Laidre Piret, Fjodorova Olga, Šamarina Ustina, Pajusalu Sander, Ilisson Mihkel, Peets Pilleriin, Jõgi Tõnu, Klaup Karin, Ojamaa Kristiina, Niine-Roolaht Eva-Maria, Kaarde Piret, Vettus Elen, Piirsoo Jüri, Vahar Helen, Õunap Katrin, Kahre Tiina

Abstract excerpt

BACKGROUND AND PURPOSE: This retrospective study provides Estonia's first nationwide overview of pathogenic and likely pathogenic variants in ovarian cancer (OC) using routine tumor molecular profiling. The aim was to characterize the mutational landscape, identify clinically actionable alterations, and evaluate the integration of germline testing. Patient/material and methods: A total of 339 OC tumor samples...

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Source

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Identifiers

PMID: 42145025
DOI: 10.2340/1651-226X.2026.45612
PMCID: PMC13192237

Genes

BRCA1
BRCA2
BRAF
KRAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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