Article
Molecular stratification of endometrioid ovarian carcinoma predicts clinical outcome.
Nature communications - 5 Oct 2020
Hollis Robert L, Thomson John P, Stanley Barbara, Churchman Michael, Meynert Alison M, Rye Tzyvia, Bartos Clare, Iida Yasushi, Croy Ian, Mackean Melanie, Nussey Fiona, Okamoto Aikou, Semple Colin A, Gourley Charlie, Herrington C Simon
Abstract excerpt
Endometrioid ovarian carcinoma (EnOC) demonstrates substantial clinical and molecular heterogeneity. Here, we report whole exome sequencing of 112 EnOC cases following rigorous pathological assessment. We detect a high frequency of mutation in CTNNB1 (43%), PIK3CA (43%), ARID1A (36%), PTEN (29%), KRAS (26%), TP53 (26%) and SOX8 (19%), a recurrently-mutated gene previously unreported in EnOC. POLE and mismatch...
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