Molecular Phenotyping Combines Molecular Information, Biological Relevance, and Patient Data to Improve Productivity of Early Drug Discovery.

doi:10.1016/j.chembiol.2017.03.016

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Molecular Phenotyping Combines Molecular Information, Biological Relevance, and Patient Data to Improve Productivity of Early Drug Discovery.

Cell chemical biology - 18 May 2017

Drawnel Faye Marie, Zhang Jitao David, Küng Erich, Aoyama Natsuyo, Benmansour Fethallah, Araujo Del Rosario Andrea, Jensen Zoffmann Sannah, Delobel Frédéric, Prummer Michael, Weibel Franziska, Carlson Coby, Anson Blake, Iacone Roberto, Certa Ulrich, Singer Thomas, Ebeling Martin, Prunotto Marco

Abstract excerpt

Today, novel therapeutics are identified in an environment which is intrinsically different from the clinical context in which they are ultimately evaluated. Using molecular phenotyping and an in vitro model of diabetic cardiomyopathy, we show that by quantifying pathway reporter gene expression, molecular phenotyping can cluster compounds based on pathway profiles and dissect associations between pathway...

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PMID: 28434878
DOI: 10.1016/j.chembiol.2017.03.016

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