Article

Predictive Modeling of Multiplex Chemical Phenomics for Novel Cells and Patients: Applied to Personalized Alzheimer’s Disease Drug Repurposing

2021-08-10

Abstract excerpt

Chemical phenomics which measures multiplex chemical-induced phenotypic response of cells or patients, particularly dose-dependent transcriptomics and drug-response curves, provides new opportunities for in silico mechanism-driven phenotype-based drug discovery. However, state-of-the-art computational methods only focus on predicting a single phenotypic readout and are less successful in screening compounds for n...

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Literature Corpus work: 7552d0ef-6c19-52c6-9564-cd0f81592e3e
DOI: 10.1101/2021.08.09.455708

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