Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Next-generation phenotypic screening.

Future medicinal chemistry - 1 Jul 2016

Warchal Scott J, Unciti-Broceta Asier, Carragher Neil O

Abstract excerpt

Phenotypic drug discovery (PDD) strategies are defined by screening and selection of hit or lead compounds based on quantifiable phenotypic endpoints without prior knowledge of the drug target. We outline the challenges associated with traditional phenotypic screening strategies and propose solutions and new opportunities to be gained by adopting modern PDD technologies. We highlight both historical and recent...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drug Evaluation, Preclinical
Share to Pharmaceutical Preparations
Share to Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27357617
DOI: 10.4155/fmc-2016-0025

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Next-generation phenotypic screening.PMID 27357617Read ↗

Innovating cancer drug discovery with refined phenotypic screens.Semantic proximity Read ↗

Improving drug discovery with high-content phenotypic screens by systematic selection of reporter cell lines.Semantic proximity Read ↗

High-content phenotypic and pathway profiling to advance drug discovery in diseases of unmet need.Semantic proximity Read ↗

The Resurrection of Phenotypic Drug DiscoverySemantic proximity Read ↗

The Power of Sophisticated Phenotypic Screening and Modern Mechanism-of-Action Methods.Semantic proximity Read ↗

Neoclassic drug discovery: the case for lead generation using phenotypic and functional approaches.Semantic proximity Read ↗

Unlocking the potential of computational phenotypic drug discovery: methods, challenges, and future directions.Semantic proximity Read ↗

Opportunities and challenges in phenotypic drug discovery: an industry perspective.Semantic proximity Read ↗

Cell and small animal models for phenotypic drug discovery.Semantic proximity Read ↗

Image-based high-content screening in drug discovery.Semantic proximity Read ↗

Phenotype-Based High-Content Screening Using Fluorescent Chemical Bioprobes: Lipid Droplets and Glucose Uptake Quantification in Live Cells.Semantic proximity Read ↗

How Phenotypic Screening Influenced Drug Discovery: Lessons from Five Years of Practice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.