Aggregated Compound Biological Signatures Facilitate Phenotypic Drug Discovery and Target Elucidation.

Abstract excerpt

Predicting the cellular response of compounds is a challenge central to the discovery of new drugs. Compound biological signatures have risen as a way of representing the perturbation produced by a compound in the cell. However, their ability to encode specific phenotypic information and generating tangible predictions remains unknown, mainly because of the inherent noise in such data sets. In this work, we...

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