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Article

The Power of Sophisticated Phenotypic Screening and Modern Mechanism-of-Action Methods.

Cell chemical biology - 21 Jan 2016

Wagner Bridget K, Schreiber Stuart L

Abstract excerpt

The enthusiasm for phenotypic screening as an approach for small-molecule discovery has increased dramatically over the last several years. The recent increase in phenotype-based discoveries is in part due to advancements in phenotypic readouts in improved disease models that recapitulate clinically relevant biology in cell culture. Of course, a major historical barrier to using phenotypic assays in chemical...

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Identifiers

PMID: 26933731
DOI: 10.1016/j.chembiol.2015.11.008
PMCID: PMC4779180

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