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The future of phenotypic drug discovery.

Cell chemical biology - 18 Mar 2021

Berg Ellen L

Abstract excerpt

Phenotypic drug discovery (PDD) uses biological systems directly for new drug screening. While PDD has proved effective in the discovery of drugs with novel mechanisms, for broader adoption, key challenges need resolution: progression of poorly qualified leads and overloaded pipelines due to lack of effective tools to process and prioritize hits; and advancement of leads with undesirable mechanisms that fail at...

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PMID: 33529582
DOI: 10.1016/j.chembiol.2021.01.010

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