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Article

MED12 mutations in leiomyosarcoma and extrauterine leiomyoma.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 May 2013

Ravegnini Gloria, Mariño-Enriquez Adrian, Slater Jaime, Eilers Grant, Wang Yuexiang, Zhu Meijun, Nucci Marisa R, George Suzanne, Angelini Sabrina, Raut Chandrajit P, Fletcher Jonathan A

Abstract excerpt

Leiomyoma and leiomyosarcoma share morphological features and smooth muscle differentiation, and both arise most frequently within the uterine corpus of middle-aged women. However, they are considered biologically unrelated tumors due to their disparate clinical, cytogenetic, and molecular features. MED12, the mediator complex subunit 12 gene, has been recently implicated as an oncogene in as many as 70% of...

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Identifiers

PMID: 23222489
DOI: 10.1038/modpathol.2012.203

Genes

MED12

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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MED12 mutations in leiomyosarcoma and extrauterine leiomyoma.PMID 23222489Read ↗

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The Mediator Complex Subunit 12 (MED-12) Gene and Uterine Fibroids: a Systematic Review.Semantic proximity Read ↗

Whole exome sequencing in a random sample of North American women with leiomyomas identifies MED12 mutations in majority of uterine leiomyomas.Semantic proximity Read ↗

Mediator complex subunit 12 exon 2 mutation analysis in different subtypes of smooth muscle tumors confirms genetic heterogeneity.Semantic proximity Read ↗

Prevalence of MED12 mutations in uterine and extrauterine smooth muscle tumours.Semantic proximity Read ↗

Mutations in Exon 1 highlight the role of MED12 in uterine leiomyomas.Semantic proximity Read ↗

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