Article
NPM1 directs PIDDosome-dependent caspase-2 activation in the nucleolus.
The Journal of cell biology - 5 Jun 2017
Ando Kiyohiro, Parsons Melissa J, Shah Richa B, Charendoff Chloé I, Paris Sheré L, Liu Peter H, Fassio Sara R, Rohrman Brittany A, Thompson Ruth, Oberst Andrew, Sidi Samuel, Bouchier-Hayes Lisa
Abstract excerpt
The PIDDosome (PIDD-RAIDD-caspase-2 complex) is considered to be the primary signaling platform for caspase-2 activation in response to genotoxic stress. Yet studies of PIDD-deficient mice show that caspase-2 activation can proceed in the absence of PIDD. Here we show that DNA damage induces the assembly of at least two distinct activation platforms for caspase-2: a cytoplasmic platform that is RAIDD dependent...
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