Article
Caspase-2 is essential for proliferation and self-renewal of nucleophosmin-mutated acute myeloid leukemia.
Science advances - 2 Aug 2024
Sakthivel Dharaniya, Brown-Suedel Alexandra N, Lopez Karla E, Salgar Suruchi, Coutinho Luiza E, Keane Francesca, Huang Shixia, Sherry Kenneth Mc, Charendoff Chloé I, Dunne Kevin P, Robichaux Dexter J, Vargas-Hernández Alexander, Le BaoChau, Shin Crystal S, Carisey Alexandre F, Poreba Marcin, Flanagan Jonathan M, Bouchier-Hayes Lisa
Abstract excerpt
Mutation in nucleophosmin (NPM1) causes relocalization of this normally nucleolar protein to the cytoplasm (NPM1c+). Despite NPM1 mutation being the most common driver mutation in cytogenetically normal adult acute myeloid leukemia (AML), the mechanisms of NPM1c+-induced leukemogenesis remain unclear. Caspase-2 is a proapoptotic protein activated by NPM1 in the nucleolus. Here, we show that caspase-2 is also...
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