Article
A redox mechanism underlying nucleolar stress sensing by nucleophosmin.
Nature communications - 25 Nov 2016
Yang Kai, Wang Ming, Zhao Yuzheng, Sun Xuxu, Yang Yi, Li Xie, Zhou Aiwu, Chu Huilin, Zhou Hu, Xu Jianrong, Wu Mian, Yang Jie, Yi Jing
Abstract excerpt
The nucleolus has been recently described as a stress sensor. The nucleoplasmic translocation of nucleolar protein nucleophosmin (NPM1) is a hallmark of nucleolar stress; however, the causes of this translocation and its connection to p53 activation are unclear. Using single live-cell imaging and the redox biosensors, we demonstrate that nucleolar oxidation is a general response to various cellular stresses....
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