Article
PICT-1 is a key nucleolar sensor in DNA damage response signaling that regulates apoptosis through the RPL11-MDM2-p53 pathway.
Oncotarget - 13 Dec 2016
Chen Hongbo, Han Liqiao, Tsai Hsiangi, Wang Zhiwei, Wu Yanping, Duo Yanhong, Cao Wei, Chen Lijun, Tan Zhirong, Xu Ning, Huang Xianzhang, Zhuang Junhua, Huang Laiqiang
Abstract excerpt
PICT-1 is an essential ribosome biogenesis factor whose loss induces p53 accumulation and apoptosis. Here, we show that DNA damage changes PICT-1 localization and decreases PICT-1 protein levels via the proteasome pathway. Two important phosphatidylinositol 3-kinase-like kinases (PIKKs), ataxia-telangiectasia mutated (ATM) and the Ku70 subunit of DNA-dependent protein kinase (DNA-PK), co-localize and interact...
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