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Article

Poly(ADP-Ribose) polymerase 1 (PARP-1) regulates ribosomal biogenesis in Drosophila nucleoli.

PLoS genetics - 1 Jan 2012

Boamah Ernest K, Kotova Elena, Garabedian Mikael, Jarnik Michael, Tulin Alexei V

Abstract excerpt

Poly(ADP-ribose) polymerase 1 (PARP1), a nuclear protein, utilizes NAD to synthesize poly(AD-Pribose) (pADPr), resulting in both automodification and the modification of acceptor proteins. Substantial amounts of PARP1 and pADPr (up to 50%) are localized to the nucleolus, a subnuclear organelle known as a region for ribosome biogenesis and maturation. At present, the functional significance of PARP1 protein inside...

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Source

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Identifiers

PMID: 22242017
DOI: 10.1371/journal.pgen.1002442
PMCID: PMC3252306

Genes

PARP1

Provenance

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