Article
A Statistical Approach to Fine Mapping for the Identification of Potential Causal Variants Related to Bone Mineral Density.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Aug 2017
Greenbaum Jonathan, Deng Hong-Wen
Abstract excerpt
Although genomewide association studies (GWASs) have been able to successfully identify dozens of genetic loci associated with bone mineral density (BMD) and osteoporosis-related traits, very few of these loci have been confirmed to be causal. This is because in a given genetic region there may exist many trait-associated SNPs that are highly correlated. Although this correlation is useful for discovering novel...
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