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Article

Improved methods for multi-trait fine mapping of pleiotropic risk loci.

Bioinformatics (Oxford, England) - 15 Jan 2017

Kichaev Gleb, Roytman Megan, Johnson Ruth, Eskin Eleazar, Lindström Sara, Kraft Peter, Pasaniuc Bogdan

Abstract excerpt

MOTIVATION: Genome-wide association studies (GWAS) have identified thousands of regions in the genome that contain genetic variants that increase risk for complex traits and diseases. However, the variants uncovered in GWAS are typically not biologically causal, but rather, correlated to the true causal variant through linkage disequilibrium (LD). To discern the true causal variant(s), a variety of statistical...

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Identifiers

PMID: 27663501
DOI: 10.1093/bioinformatics/btw615
PMCID: PMC5254076

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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