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Article

mTORC1 Promotes T-bet Phosphorylation To Regulate Th1 Differentiation.

Journal of immunology (Baltimore, Md. : 1950) - 15 May 2017

Chornoguz Olesya, Hagan Robert S, Haile Azeb, Arwood Matthew L, Gamper Christopher J, Banerjee Arnob, Powell Jonathan D

Abstract excerpt

CD4+ T cells lacking the mTORC1 activator Rheb fail to secrete IFN-γ under Th1 polarizing conditions. We hypothesized that this phenotype is due to defects in regulation of the canonical Th1 transcription factor T-bet at the level of protein phosphorylation downstream of mTORC1. To test this hypothesis, we employed targeted mass-spectrometry proteomic analysis-multiple reaction monitoring mass spectrometry. We...

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Identifiers

PMID: 28424242
DOI: 10.4049/jimmunol.1601078
PMCID: PMC5458608

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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