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Article

Regulation of Th17 Differentiation by IKKα-Dependent and -Independent Phosphorylation of RORγt.

Journal of immunology (Baltimore, Md. : 1950) - 1 Aug 2017

He Zhiheng, Wang Fei, Zhang Jing, Sen Subha, Pang Qihua, Luo Shengwei, Gwack Yousang, Sun Zuoming

Abstract excerpt

Transcription factor retinoid acid-related orphan receptor (ROR)γt transcriptionally regulates the genes required for differentiation of Th17 cells that mediate both protective and pathogenic immunity. However, little is known about the function of posttranslational modifications in the regulation of RORγt activity. Mass spectrometric analysis of immunoprecipitated RORγt from Th17 cells identified multiple...

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Identifiers

PMID: 28667162
DOI: 10.4049/jimmunol.1700457
PMCID: PMC5531059

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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