Use of BRAF immunohistochemistry as a screening test in detecting BRAFV600E mutation in melanomas.

Abstract excerpt

OBJECTIVE: BRAF mutation is detected in 50-70% of melanomas. The molecular methods used to detect BRAF mutations are 80-90% sensitive, specific, and expensive methods. Immunohistochemistry is a relatively common, rapid, relatively inexpensive method in pathology practice compared to molecular techniques. AIMS: We aimed to compare immunohistochemical and molecular methods in our case of malign melanoma in which we...

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