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Article

Examining the Causal Role of Leptin in Alzheimer Disease: A Mendelian Randomization Study.

Neuroendocrinology - 1 Jan 2017

Romo Matthew L, Schooling C Mary

Abstract excerpt

BACKGROUND: Observational evidence regarding the role of leptin in Alzheimer disease (AD) is conflicting. We sought to determine the causal role of circulating leptin and soluble plasma leptin receptor (sOB-R) levels in AD using a separate-sample Mendelian randomization study. METHODS: Single nucleotide polymorphisms (SNPs) independently and solely predictive of log-transformed leptin (rs10487505 [LEP], rs780093...

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Source

Identifiers

PMID: 28419997
DOI: 10.1159/000475713

Genes

LEPR
CCNL1
GCKR
LEP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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