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Article

Revisiting the Effect of Leptin on Alzheimer Disease and Parkinson Disease: The Role of Insulin Sensitivity.

The Journal of clinical endocrinology and metabolism - 13 Aug 2024

Guo Xingzhi, Tang Peng, Zhang Xin, Li Rui

Abstract excerpt

CONTEXT: Studies have indicated a link between leptin, Alzheimer disease (AD), and Parkinson disease (PD). However, the causal relationship among them remains not well established due to confounders and reverse causation. OBJECTIVE: This Mendelian randomization (MR) study was performed to evaluate the impact and potential mechanism of leptin and its soluble receptor on AD and PD. METHODS: Utilizing genome-wide...

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Source

Identifiers

PMID: 38441543
DOI: 10.1210/clinem/dgae136

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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