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Article

Aurora kinase B dependent phosphorylation of 53BP1 is required for resolving merotelic kinetochore-microtubule attachment errors during mitosis.

Oncotarget - 25 Jul 2017

Wang Haibo, Peng Bin, Pandita Raj K, Engler David A, Matsunami Risë K, Xu Xingzhi, Hegde Pavana M, Butler Brian E, Pandita Tej K, Mitra Sankar, Xu Bo, Hegde Muralidhar L

Abstract excerpt

Defects in resolving kinetochore-microtubule attachment mistakes during mitosis is linked to chromosome instability associated with carcinogenesis as well as resistance to cancer therapy. Here we report for the first time that tumor suppressor p53-binding protein 1 (53BP1) is phosphorylated at serine 1342 (S1342) by Aurora kinase B both in vitro and in human cells, which is required for optimal recruitment of...

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Identifiers

PMID: 28415769
DOI: 10.18632/oncotarget.16225
PMCID: PMC5564716

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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