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Article

Epigenetic up-regulation of ribosome biogenesis and more aggressive phenotype triggered by the lack of the histone demethylase JHDM1B in mammary epithelial cells.

Oncotarget - 6 Jun 2017

Galbiati Alice, Penzo Marianna, Bacalini Maria Giulia, Onofrillo Carmine, Guerrieri Ania Naila, Garagnani Paolo, Franceschi Claudio, Treré Davide, Montanaro Lorenzo

Abstract excerpt

The alterations of ribosome biogenesis and protein synthesis play a direct role in the development of tumors. The accessibility and transcription of ribosomal genes is controlled at several levels, with their epigenetic regulation being one of the most important. Here we explored the JmjC domain-containing histone demethylase 1B (JHDM1B) function in the epigenetic control of rDNA transcription. Since JHDM1B is a...

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Identifiers

PMID: 28415746
DOI: 10.18632/oncotarget.16181
PMCID: PMC5514893

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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