Article
JmjN interacts with JmjC to ensure selective proteolysis of Gis1 by the proteasome.
Microbiology (Reading, England) - 1 Sept 2011
Quan Zhenzhen, Oliver Stephen G, Zhang Nianshu
Abstract excerpt
A group of JmjC domain-containing proteins also harbour JmjN domains. Although the JmjC domain is known to possess histone demethylase activity, the function of the JmjN domain remains largely undetermined. Previously, we have demonstrated that the yeast Gis1 transcription factor, bearing both JmjN and JmjC domains at its N terminus, is subject to proteasome-mediated selective proteolysis to downregulate its...
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