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Article

Mammalian WDR12 is a novel member of the Pes1-Bop1 complex and is required for ribosome biogenesis and cell proliferation.

The Journal of cell biology - 1 Aug 2005

Hölzel Michael, Rohrmoser Michaela, Schlee Martin, Grimm Thomas, Harasim Thomas, Malamoussi Anastassia, Gruber-Eber Anita, Kremmer Elisabeth, Hiddemann Wolfgang, Bornkamm Georg W, Eick Dirk

Abstract excerpt

Target genes of the protooncogene c-myc are implicated in cell cycle and growth control, yet the linkage of both is still unexplored. Here, we show that the products of the nucleolar target genes Pes1 and Bop1 form a stable complex with a novel member, WDR12 (PeBoW complex). Endogenous WDR12, a WD40 repeat protein, is crucial for processing of the 32S precursor ribosomal RNA (rRNA) and cell proliferation....

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Identifiers

PMID: 16043514
DOI: 10.1083/jcb.200501141
PMCID: PMC2171466

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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