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Article

HSPC111 Governs Breast Cancer Growth by Regulating Ribosomal Biogenesis

15 Jan 2014

Abstract excerpt

UNLABELLED: Activation of c-Myc plays a decisive role in the development of many human cancers. As a transcription factor, c-Myc facilitates cell growth and proliferation by directly transcribing a multitude of targets, including rRNAs and ribosome proteins. However, how to elucidate the deregulation of rRNAs and ribosome proteins driven by c-Myc in cancer remains a significant challenge and thus warrants close...

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PMID: 24425784
DOI: 10.1158/1541-7786.mcr-13-0168

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