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L1000CDS2: LINCS L1000 characteristic direction signatures search engine

4 Aug 2016

Abstract excerpt

The library of integrated network-based cellular signatures (LINCS) L1000 data set currently comprises of over a million gene expression profiles of chemically perturbed human cell lines. Through unique several intrinsic and extrinsic benchmarking schemes, we demonstrate that processing the L1000 data with the characteristic direction (CD) method significantly improves signal to noise compared with the MODZ...

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PMID: 28413689
DOI: 10.1038/npjsba.2016.15

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