Article

OCTAD: an open workplace for virtually screening therapeutics targeting precise cancer patient groups using gene expression features

2019-11-01

Abstract excerpt

One approach to precision medicine is to discover drugs that target molecularly defined diseases. Voluminous cancer patient gene expression profiles have been accumulated in public databases, enabling the creation of a cancer-specific expression signature. By matching this signature to perturbagen-induced gene expression profiles from large drug libraries, researchers can prioritize small molecules that present hi...

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Literature Corpus work: 33bd8149-71f3-53dd-975a-3421aec74428
DOI: 10.1101/821546

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