Article

A Next Generation Connectivity Map: L1000 Platform And The First 1,000,000 Profiles

2017-05-10

Abstract excerpt

<h4>SUMMARY</h4> We previously piloted the concept of a Connectivity Map (CMap), whereby genes, drugs and disease states are connected by virtue of common gene-expression signatures. Here, we report more than a 1,000-fold scale-up of the CMap as part of the NIH LINCS Consortium, made possible by a new, low-cost, high throughput reduced representation expression profiling method that we term L1000. We show that L1...

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Literature Corpus work: 368a9803-2f50-5916-a673-bbba3bdf2c17
DOI: 10.1101/136168

Open publication

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