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SUV39H1 regulates the progression of MLL-AF9-induced acute myeloid leukemia

9 Oct 2020

Abstract excerpt

Epigenetic regulations play crucial roles in leukemogenesis and leukemia progression. SUV39H1 is the dominant H3K9 methyltransferase in the hematopoietic system, and its expression declines with aging. However, the role of SUV39H1 via its-mediated repressive modification H3K9me3 in leukemogenesis/leukemia progression remains to be explored. We found that SUV39H1 was down-regulated in a variety of leukemias,...

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PMID: 33037410
DOI: 10.1038/s41388-020-01495-6

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