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The stem cell factor SALL4 is an essential transcriptional regulator in mixed lineage leukemia-rearranged leukemogenesis

3 Oct 2017

Abstract excerpt

The stem cell factor spalt-like transcription factor 4 (SALL4) plays important roles in normal hematopoiesis and also in leukemogenesis. We previously reported that SALL4 exerts its effect by recruiting important epigenetic factors such as DNA methyltransferases DNMT1 and lysine-specific demethylase 1 (LSD1/KDM1A). Both of these proteins are critically involved in mixed lineage leukemia (MLL)-rearranged (MLL-r)...

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Acute Lymphoblastic Leukemia research
Renal and related cancers
Zebrafish Biomedical Research Applications

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 28974232
DOI: 10.1186/s13045-017-0531-y

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