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Article

Potent Vasoconstrictor Kisspeptin-10 Induces Atherosclerotic Plaque Progression and Instability: Reversal by its Receptor GPR54 Antagonist.

Journal of the American Heart Association - 14 Apr 2017

Sato Kengo, Shirai Remina, Hontani Mina, Shinooka Rina, Hasegawa Akinori, Kichise Tomoki, Yamashita Tomoyuki, Yoshizawa Hayami, Watanabe Rena, Matsuyama Taka-Aki, Ishibashi-Ueda Hatsue, Koba Shinji, Kobayashi Youichi, Hirano Tsutomu, Watanabe Takuya

Abstract excerpt

BACKGROUND: Kisspeptin-10 (KP-10), a potent vasoconstrictor and inhibitor of angiogenesis, and its receptor, GPR54, have currently received much attention in relation to pre-eclampsia. However, it still remains unknown whether KP-10 could affect atherogenesis. METHODS AND RESULTS: We evaluated the effects of KP-10 on human umbilical vein endothelial cells, human monocyte-derived macrophages, human aortic smooth...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Kisspeptins

Share to Myocytes, Smooth Muscle

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Source

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Identifiers

PMID: 28411243
DOI: 10.1161/JAHA.117.005790
PMCID: PMC5533042

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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