Article
Smooth Muscle Peroxisome Proliferator-Activated Receptor γ Plays a Critical Role in Formation and Rupture of Cerebral Aneurysms in Mice In Vivo.
Hypertension (Dallas, Tex. : 1979) - 1 Jul 2015
Hasan David M, Starke Robert M, Gu He, Wilson Katina, Chu Yi, Chalouhi Nohra, Heistad Donald D, Faraci Frank M, Sigmund Curt D
Abstract excerpt
Vascular inflammation plays a critical role in the pathogenesis of cerebral aneurysms. Peroxisome proliferator-activated receptor γ (PPARγ) protects against vascular inflammation and atherosclerosis, whereas dominant-negative mutations in PPARγ promote atherosclerosis and vascular dysfunction. We tested the role of PPARγ in aneurysm formation and rupture. Aneurysms were induced with a combination of systemic...
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