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Article

Pro-Inflammatory Activation Promotes Atherogenic Endothelial Phenotype in Male and Female Human Umbilical Endothelial Vein Cells (HUVECs).

International journal of molecular sciences - 27 Mar 2026

Lorenz Mario, Palant Riwka, Oscherowa Edith, Karmid-Haj Hamoud Weam, Kirwan Jennifer A, Trajkovski Sarah, Wiebach Janine, Fritsche-Guenther Raphaela, Wu Haiyan, Haritonow Natalie, Vietzke Angelika, Kaschina Elena, Henrich Wolfgang, Temp Julia, Barcena Maria Luisa

Abstract excerpt

Atherosclerosis, the leading global cause of death, is a chronic inflammatory vascular disease with higher prevalence and earlier onset in men than in women. This study aims to investigate sex differences in the atherogenic endothelial phenotype during early atherosclerosis processes by providing the first comprehensive analysis of hormone-independent responses in human umbilical vein endothelial cells (HUVECs)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41977266
DOI: 10.3390/ijms27073079
PMCID: PMC13073718

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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