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Kisspeptins: a multifunctional peptide system with a role in reproduction, cancer and the cardiovascular system

29 May 2007

Abstract excerpt

Orphan G-protein-coupled receptors that have recently been paired with their cognate ligand are an often untapped resource for novel drug development. The KISS1 receptor (previously designated GPR54) has been paired with biologically active cleavage peptides of the KiSS-1 gene product, the kisspeptins (KP). The focus of this review is the emerging pharmacology and physiology of the KP. Genetic linkage analysis in...

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PMID: 17519946
DOI: 10.1038/sj.bjp.0707295

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