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Article

The soluble (pro)renin receptor promotes a preeclampsia-like phenotype both in vitro and in vivo.

Hypertension research : official journal of the Japanese Society of Hypertension - 1 Jun 2024

Schofield Lachlan G, Delforce Sarah J, Pryor Jennifer C, Endacott Saije K, Lumbers Eugenie R, Marshall Sarah A, Pringle Kirsty G

Abstract excerpt

Preeclampsia is classified as new-onset hypertension coupled with gross endothelial dysfunction. Placental (pro)renin receptor ((P)RR) and plasma soluble (P)RR (s(P)RR) are elevated in patients with preeclampsia. Thus, we aimed to interrogate the role (P)RR may play in the pathogenesis of preeclampsia. Human uterine microvascular endothelial cells (HUtMECs, n = 4) were cultured with either; vehicle (PBS),...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38605139
DOI: 10.1038/s41440-024-01678-8
PMCID: PMC11150152

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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