Article
Low interleukin-2 concentration favors generation of early memory T cells over effector phenotypes during chimeric antigen receptor T-cell expansion.
Cytotherapy - 1 Jun 2017
Kaartinen Tanja, Luostarinen Annu, Maliniemi Pilvi, Keto Joni, Arvas Mikko, Belt Heini, Koponen Jonna, Mäkinen Petri I, Loskog Angelica, Mustjoki Satu, Porkka Kimmo, Ylä-Herttuala Seppo, Korhonen Matti
Abstract excerpt
BACKGROUND: Adoptive T-cell therapy offers new options for cancer treatment. Clinical results suggest that T-cell persistence, depending on T-cell memory, improves efficacy. The use of interleukin (IL)-2 for in vitro T-cell expansion is not straightforward because it drives effector T-cell differentiation but does not promote the formation of T-cell memory. We have developed a cost-effective expansion protocol...
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