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Article

Phenotypic Composition of Commercial Anti-CD19 CAR T Cells Affects In Vivo Expansion and Disease Response in Patients with Large B-cell Lymphoma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 2 Aug 2022

Monfrini Chiara, Stella Federico, Aragona Vanessa, Magni Martina, Ljevar Silva, Vella Cristina, Fardella Eugenio, Chiappella Annalisa, Nanetti Francesca, Pennisi Martina, Dodero Anna, Guidetti Anna, Corradini Paolo, Carniti Cristiana

Abstract excerpt

PURPOSE: In clinical trials, the expansion and persistence of chimeric antigen receptor (CAR) T cells correlate with therapeutic efficacy. However, properties of CAR T cells that enable their in vivo proliferation have still to be consistently defined and the role of CAR T bag content has never been investigated in a real-life setting. EXPERIMENTAL DESIGN: Residual cells obtained after washing 61 anti-CD19 CAR T...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Immunotherapy, Adoptive

Share to Lymphoma, Large B-Cell, Diffuse

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Source

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Identifiers

PMID: 35583610
DOI: 10.1158/1078-0432.CCR-22-0164
PMCID: PMC9662896

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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