Leukocyte Overexpression of Intracellular NAMPT Attenuates Atherosclerosis by Regulating PPARγ-Dependent Monocyte Differentiation and Function.

doi:10.1161/ATVBAHA.116.308187

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Article

Leukocyte Overexpression of Intracellular NAMPT Attenuates Atherosclerosis by Regulating PPARγ-Dependent Monocyte Differentiation and Function.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jun 2017

Bermudez Beatriz, Dahl Tuva Borresdatter, Medina Indira, Groeneweg Mathijs, Holm Sverre, Montserrat-de la Paz Sergio, Rousch Mat, Otten Jeroen, Herias Veronica, Varela Lourdes M, Ranheim Trine, Yndestad Arne, Ortega-Gomez Almudena, Abia Rocio, Nagy Laszlo, Aukrust Pal, Muriana Francisco J G, Halvorsen Bente, Biessen Erik Anna Leonardus

Abstract excerpt

OBJECTIVE: Extracellular nicotinamide phosphoribosyltransferase (eNAMPT) mediates inflammatory and potentially proatherogenic effects, whereas the role of intracellular NAMPT (iNAMPT), the rate limiting enzyme in the salvage pathway of nicotinamide adenine dinucleotide (NAD)+ generation, in atherogenesis is largely unknown. Here we investigated the effects of iNAMPT overexpression in leukocytes on inflammation...

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PMID: 28408371
DOI: 10.1161/ATVBAHA.116.308187

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NAMPT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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