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Extension of Human Cell Lifespan by Nicotinamide Phosphoribosyltransferase

17 Feb 2007

Abstract excerpt

Extending the productive lifespan of human cells could have major implications for diseases of aging, such as atherosclerosis. We identified a relationship between aging of human vascular smooth muscle cells (SMCs) and nicotinamide phosphoribosyltransferase (Nampt/PBEF/Visfatin), the rate-limiting enzyme for NAD+ salvage from nicotinamide. Replicative senescence of SMCs was preceded by a marked decline in the...

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PMID: 17307730
DOI: 10.1074/jbc.c700018200

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