Article
CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD+ and NMN levels.
Nature metabolism - 1 Nov 2020
Chini Claudia C S, Peclat Thais R, Warner Gina M, Kashyap Sonu, Espindola-Netto Jair Machado, de Oliveira Guilherme C, Gomez Lilian S, Hogan Kelly A, Tarragó Mariana G, Puranik Amrutesh S, Agorrody Guillermo, Thompson Katie L, Dang Kevin, Clarke Starlynn, Childs Bennett G, Kanamori Karina S, Witte Micaela A, Vidal Paola, Kirkland Anna L, De Cecco Marco, Chellappa Karthikeyani, McReynolds Melanie R, Jankowski Connor, Tchkonia Tamara, Kirkland James L, Sedivy John M, van Deursen Jan M, Baker Darren J, van Schooten Wim, Rabinowitz Joshua D, Baur Joseph A, Chini Eduardo N
Abstract excerpt
Decreased NAD+ levels have been shown to contribute to metabolic dysfunction during aging. NAD+ decline can be partially prevented by knockout of the enzyme CD38. However, it is not known how CD38 is regulated during aging, and how its ecto-enzymatic activity impacts NAD+ homeostasis. Here we show that an increase in CD38 in white adipose tissue (WAT) and the liver during aging is mediated by accumulation of...
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