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Article

FOXF1 Transcription Factor Is Required for Formation of Embryonic Vasculature by Regulating VEGF Signaling in Endothelial Cells

5 Aug 2014

Abstract excerpt

RATIONALE: Inactivating mutations in the Forkhead Box transcription factor F1 (FOXF1) gene locus are frequently found in patients with alveolar capillary dysplasia with misalignment of pulmonary veins, a lethal congenital disorder, which is characterized by severe abnormalities in the respiratory, cardiovascular, and gastrointestinal systems. In mice, haploinsufficiency of the Foxf1 gene causes alveolar capillary...

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PMID: 25091710
DOI: 10.1161/circresaha.115.304382

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FOXF1 Transcription Factor Is Required for Formation of Embryonic Vasculature by Regulating VEGF Signaling in Endothelial CellsPMID 25091710Read ↗

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The forkhead box m1 transcription factor is essential for embryonic development of pulmonary vasculature.Semantic proximity Read ↗

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The molecular consequences of FOXF1 missense mutations associated with alveolar capillary dysplasia with misalignment of pulmonary veinsSemantic proximity Read ↗

Perturbation of semaphorin and VEGF signaling in ACDMPV lungs due to FOXF1 deficiencySemantic proximity Read ↗

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A familial case of alveolar capillary dysplasia with misalignment of pulmonary veins supports paternal imprinting of FOXF1 in humanSemantic proximity Read ↗

Disruption of normal patterns of FOXF1 expression in a lethal disorder of lung development.Semantic proximity Read ↗

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